Which factor can enhance drug distribution in body tissues?

The factor that enhances drug distribution in body tissues is increased blood flow to those tissues. When blood flow is elevated, it facilitates the transport of drugs from the bloodstream to the tissues where they exert their therapeutic effects. This is particularly important in tissues that may initially have a lower concentration of the drug. Enhanced blood flow can occur during situations such as physical exercise or inflammation, leading to a more rapid and effective distribution of drugs throughout the body.

High plasma protein binding can actually limit the amount of free drug available for distribution, as only unbound drugs can cross cell membranes and reach target tissues. Low tissue permeability is a barrier to drug distribution, as drugs need to penetrate cell membranes to enter tissues effectively. Slow metabolism can influence the duration of a drug’s action but does not directly enhance distribution; rather, it may lead to prolonged circulation in the bloodstream without ensuring effective delivery to tissues. Thus, increased blood flow plays a crucial role in improving the distribution of drugs to various body tissues.