Which condition is NOT typically associated with altered protein binding?

Altered protein binding refers to changes in the ability of drugs to bind to plasma proteins, which can impact the availability of the drug in its active form in the body. Conditions that can affect protein binding typically involve changes in protein levels, the presence of competing substances, or alterations in the physiological condition of the individual.

Hypertension, typically characterized by elevated blood pressure, does not inherently lead to significant changes in plasma protein levels or binding sites. While comorbidities and complications can arise from chronic hypertension, the condition itself does not include mechanisms that would broadly affect protein binding of drugs.

In contrast, conditions such as Crohn's Disease can lead to malabsorption and altered nutritional status, thereby impacting the levels of plasma proteins like albumin. Acute Myocardial Infarction can alter hemodynamics and perhaps lead to changes in albumin levels and other protein concentrations due to stress and tissue injury. Severe Burns can cause significant loss of albumin and other proteins, altering drug pharmacokinetics by decreasing binding sites.

Hence, hypertension is the condition that is least likely to be associated with altered protein binding compared to the others listed.