What is one advantage of intranasal administration of drugs?

Intranasal administration of drugs presents a significant advantage by avoiding the first-pass effect. When a drug is administered orally, it passes through the gastrointestinal tract and is metabolized by the liver before it enters the systemic circulation. This metabolism can significantly reduce the amount of active drug that reaches the bloodstream, potentially diminishing the intended therapeutic effect.

In contrast, intranasal administration allows the drug to be absorbed directly through the nasal mucosa into the systemic circulation. This route bypasses the liver's first-pass metabolism, leading to higher bioavailability and potentially more effective outcomes. This method is particularly beneficial for drugs that have poor oral bioavailability due to extensive first-pass metabolism.

The other options reflect less favorable characteristics of drug administration via alternative routes, such as lower bioavailability, gastrointestinal irritation, or the need for more frequent dosing, which do not correlate with the primary benefits of intranasal delivery.