What does increased drug accumulation in elderly patients typically indicate?

Increased drug accumulation in elderly patients typically indicates an increased risk of adverse effects. As individuals age, their bodies undergo various physiological changes, such as decreased renal and hepatic function, which can lead to slower drug clearance from the body. This impaired elimination can result in higher concentrations of the drug in the bloodstream, potentially heightening the likelihood and severity of side effects.

Moreover, elderly patients often have comorbidities, multiple prescriptions, and altered pharmacodynamics, which can further complicate drug therapy and increase the risk of adverse effects. Therefore, monitoring drug levels and adjusting dosages carefully in elderly patients is crucial to minimize the risk of toxicity and ensure safe and effective medication management.