Drugs that bind to alpha-acid glycoproteins (AAG) are usually?

Drugs that bind to alpha-acid glycoproteins (AAG) are generally slightly basic in nature. AAG is a plasma protein that plays a significant role in the distribution and pharmacokinetics of various medications. It has a higher affinity for basic compounds, thus leading to the binding of drugs with slightly basic properties.

Drugs like diazepam and midazolam, which are known to have some basic characteristics, can readily associate with AAG. This binding can influence their distribution, metabolism, and elimination processes within the body, ultimately affecting their therapeutic efficacy and safety profile.

Understanding the interaction between drugs and plasma proteins, such as AAG, is crucial for predicting how these medications behave in the body, especially concerning bioavailability, half-life, and dosing adjustments needed in specific patient populations.